Table 1.
Synthetic modulators of cannabinoid receptor function.
| Name | Activity at CB1 (Ki in nM) | Activity at CB2 (Ki in nM) | Comments | References |
|---|---|---|---|---|
| ACEA | 1.4 ± 0.3 | >2000 | Selective CB1 receptor agonist | Lipina et al. (2010), Tedesco et al. (2010) |
| AM251 | 7.5 | 2000–3000 | Selective CB1 receptor antagonist/inverse agonist | Eckardt et al. (2009) |
| SR141716 | 1.8 ± 0.2 | – | Selective CB1 receptor antagonist/inverse agonist | Jbilo et al. (2005), Huang et al. (2010) |
| JWH-133 | 680 | 3.4 | Selective CB2 receptor agonist | Li et al. (2013) |
| AM-630 | 5.2 × 103 | 31.2 | Selective CB2 receptor antagonist/ inverse agonist | Deveaux et al. (2009) |
| CP 55,940 | 0.5 ± 0.1 | 2.8 ± 0.4 | Non-selective potent CB1/2 receptor agonist | South and Huang (2008) |
| HU-210 | 0.1–0.7 | 0.2–0.5 | Non-selective potent CB1/2 receptor agonist | Athanasiou et al. (2007) |
| WIN 55,212-2 | 4.4 ± 1.3 | 1.2 ± 0.25 | Non-selective CB1/2 receptor agonist | Gustafsson et al. (2006) |
Citations refer to studies performed using the compounds listed in order to elucidate the functional role of CB1R and/or CB2R.