Table 2.
Variables Distribution at t0 and t25 and Corresponding Comparisons
| St0 | St25 | HCSt0 | HCSt25 | St0 vs. St25 | HCSt0 vs. HCSt25 | St0 vs. HCSt0 | St25 vs. HCSt25 | |
|---|---|---|---|---|---|---|---|---|
| Variable | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | p | p | p | p |
| Corneometry | 36.09 (30.03, 43.11) | 34.67 (32.2, 42.77) | 40.73 (32.2, 57.72) | 39.91 (37.59, 46.63) | 0.8640 | 0.4582 | 0.1737 | 0.1882 |
| TEWL | 6.85 (4.78, 8.75) | 8.9 (5.5, 11.6) | 8.35 (4.77, 11.22) | 6.85 (4.25, 12.1) | 0.4932 | 0.2702 | 0.3792 | 0.6849 |
| Melanin | 188.46 (140, 223.25) | 146.83 (128, 191.08) | 163.29 (135.09, 218.17) | 144 (112.54, 185.66) | 0.0063* | 0.0006† | 0.7694 | 0.3569 |
| Erythema | 299.84 (263.84, 357.55) | 291.5 (255.41, 325.5) | 250.83 (170.92, 317.08) | 241.84 (199.29, 296.17) | 0.3803 | 0.7084 | 0.0892 | 0.0941 |
| L | 65.48 (63.19, 68.51) | 66.62 (63.25, 68.5) | 66.25 (59.75, 68.83) | 66.98 (64.01, 69.37) | 0.9134 | 0.0197* | 0.7075 | 0.6588 |
| A | 12.84 (10.88, 13.74) | 12.28 (11.28, 12.98) | 11.26 (9.9, 13.44) | 10.96 (9.91, 12.04) | 0.6813 | 0.3378 | 0.4238 | 0.0787 |
| B | 12.03 (10.61, 13.16) | 11.95 (10.49, 13.5) | 13.73 (12.09, 15.38) | 12.44 (10.98, 13.55) | 0.5289 | 0.0427* | 0.0223* | 0.3483 |
| ITA | 53.16 (43.83, 58.42) | 52.67 (48.5, 57.71) | 50.34 (36.42, 55.75) | 52.84 (45.17, 58.5) | 0.8590 | 0.0045** | 0.2187 | 0.9892 |
| Ra | 21.75 (19, 24.38) | 19.25 (17.75, 22.75) | 20.5 (19, 22.75) | 20 (19, 23.25) | 0.0002† | 0.3075 | 0.7449 | 0.3356 |
| Rmax | 153.25 (123.75, 175) | 139 (120.88, 157.5) | 133 (121.25, 161.25) | 141.5 (126.75, 155.75) | 0.0002† | 0.8959 | 0.5338 | 0.5323 |
| R0 | 0.12 (0.08, 0.2) | 0.12 (0.06, 0.19) | 0.20 (0.13, 0.27) | 0.12 (0.08, 0.24) | 0.3424 | 0.0076* | 0.0228* | 0.2447 |
| R2 | 0.75 (0.68, 0.84) | 0.83 (0.62, 0.86) | 0.79 (0.73, 0.83) | 0.80 (0.71, 0.83) | 0.4222 | 0.2984 | 0.1969 | 0.4488 |
| R5 | 0.47 (0.4, 0.55) | 0.51 (0.32, 0.57) | 0.66 (0.56, 0.76) | 0.63 (0.57, 0.69) | 0.8698 | 0.3225 | 0.0042* | 0.0116* |
Comparisons between time points (i.e., St0 vs. St25 and HCSt0 vs. HCSt25) were performed by the Student's t-test for paired samples or by the Wilcoxon test for paired samples; comparisons between treatments at the same time point were performed by the Student's t-test for unpaired samples or by the Wilcoxon rank-sum test for unpaired samples (i.e., St0 vs. HCSt0 and St25 vs. HCSt25).
St0 = median (25th, 75th percentiles, IQR) of each variable's distribution in scars at t0.
St25 = median (25th, 75th percentiles, IQR) of each variable's distribution in scars at t25.
HCSt0 = median (25th, 75th percentiles, IQR) of each variable's distribution in healthy contralateral skin sites at t0.
HCSt25 = median (25th, 75th percentiles, IQR) of each variable's distribution in healthy contralateral skin sites at t25.
St0 versus St25 = p value deriving from the comparison of each variable's distribution between t0 and t25 measurements in scars.
HCSt0 versus HCSt25 = p value deriving from the comparison of each variable's distribution between t0 and t25 measurements in healthy contralateral skin sites.
St0 versus HCSt0 = p value deriving from the comparison of each variable's distribution between measurements in scars and healthy contralateral skin sites at t0.
St25 versus HCSt25 = p value deriving from the comparison of each variable's distribution between measurements in scars and healthy contralateral skin sites at t25.
Variable = analyzed variable.
HCS, healthy contralateral skin sites; IQR, interquartile range; S, scars; TEWL, transepidermal water loss.
p Value <0.05.
†p Value <0.004 based on the Bonferroni correction for multiple testing.