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. Author manuscript; available in PMC: 2017 May 22.
Published in final edited form as: J Alzheimers Dis. 2016 Sep 6;54(2):669–678. doi: 10.3233/JAD-160036

Fig. 1.

Fig. 1

Levels of eEF1A in hippocampus are decreased by Aβ and in an AD model mice. (A) Western blot experiments on WT hippocampal slices reveal decreased expression of eEF1A following treatment with 500 nM synthetic Aβ. Cumulative data are shown in the bar graph accompanied by representative blots. n = 8 for vehicle, n = 10 for Aβ. Unpaired independent t test. *p < 0.05. (B) Hippocampi from Tg2576 AD model mice (Tg) also exhibit decreased levels of eEF1A compared to WT littermates. Moreover, 1 μM rapamycin (Rapa) treatment results in downregulation of eEF1A levels in WT slices, with no effects on slices from Tg mice. Cumulative data are shown in bar graphs accompanied by representative blots. n = 9 for WT, n = 3 for WT+Rapa, n = 10 for Tg, n = 5 for Tg+Rapa. Unpaired independent t test. *p < 0.05, **p < 0.01