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Conditional TSC2 knockout mice. Forebrain-specific TSC2 knockout mice (TSC2+/−) demonstrated (A) reduction of TSC2 protein levels (n = 4) and (B) elevated eEF1A protein levels (n = 10 for WT, n = 7 for TSC2+/−) in hippocampal tissue. (C) Aβ-induced decreases in eEF1A expression are blunted in TSC2+/− hippocampal slices (n = 3 for vehicle, n = 5 for Aβ). Cumulative data are shown in bar graphs with representative blots; unpaired independent t-test; *p < 0.05.
