Fig. 2.

—Homologous regions among Ska-C and Dam1-C subunits. Regions of homology, microtubule-binding (“MT-binding”), coiled-coils and pairwise interactions in the homologous clusters Ska1-Ska2-Ska3 (A), Duo1-Dad2 (B) and Dad1-Dad4-Ask1 (C). For the Ska-C subunits, the coiled-coil and interaction regions are based on the structure of this complex in H. sapiens (Jeyaprakash et al. 2012), for the Dam1-C subunits the coiled-coil regions are based on predictions and the interaction sites were derived from published cross-linking/mass spectrometry analyses in S. cerevisiae (Zelter et al. 2015). Although not found by profile–profile searches, the red striped region in (A) is proposed to be homologous to Ska1/2 coiled coil region based on structural similarities.