Table 3. Associations of weight change from pre-diagnosis to 18-month post-diagnosis with TNBC survival, stratified by pre-diagnostic BMI and menopausal status.
| Weight change from pre-diagnosis to post-diagnosis a | |||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Stable within 5% | Gain (≥ 5 %) | Loss (≥ 5 %) | P for interaction | ||||
|
|
|
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| Total/Event | HR | Total/Event | HR (95% CI) | Total/Event | HR (95% CI) | ||
| Total mortality | |||||||
| Total | 247/45 | 1.00 | 184/38 | 1.26(0.80,2.00) | 42/27 | 2.08(1.25,3.46) | |
| Stratified by pre-diagnostic BMI | |||||||
| <24.0 | 121/19 | 1.00 | 142/25 | 1.13(0.60,2.13) | 27/12 | 1.73(0.74,4.04) | |
| ≥24.0 | 125/25 | 1.00 | 42/13 | 1.88(0.92,3.85) | 42/15 | 2.15(1.09,4.26) | 0.48 |
| Stratified by menopausal status at baseline | |||||||
| Premenopausal | 99/8 | 1.00 | 118/24 | 2.84(1.23,6.58) | 20/7 | 6.22(2.13,8.13) | |
| Postmenopausal | 148/37 | 1.00 | 66/14 | 0.95(0.50,1.80) | 49/20 | 1.64(0.91,2.98) | 0.46 |
|
| |||||||
| Recurrence/disease-specific mortality | |||||||
| Total | 247/37 | 1.00 | 184/35 | 1.32(0.81,2.15) | 69/25 | 2.50(1.45,4.30) | |
| Stratified by pre-diagnostic BMI a | |||||||
| <24.0 | 121/17 | 1.00 | 142/25 | 1.30(0.67,2.50) | 27/10 | 1.80(0.72,4.52) | |
| ≥24.0 | 125/20 | 1.00 | 42/10 | 1.91(0.85,4.31) | 42/15 | 2.65(1.28,5.46) | 0.86 |
| Stratified by menopausal status at baseline | |||||||
| Premenopausal | 99/9 | 1.00 | 118/23 | 2.38(1.08,5.25) | 20/8 | 7.26(2.62,20.11) | |
| Postmenopausal | 148/28 | 1.00 | 65/12 | 1.01(0.50,2.05) | 49/17 | 1.92(0.98,3.79) | 0.59 |
a
HRs from Cox regression models and adjusted for age at diagnosis (continuous variable), education (<high school, high school, >high school), Charlson comorbidity index (0, ≥ 1), menopausal status at baseline (yes, no), exercise participation at baseline (yes, no), type of surgery received, chemotherapy (yes, no), radiotherapy (yes, no), and TNM stage (I, II, III, unknown)