Table 1. Patient characteristics (n = 21).
| No. (%) or Median (95% CI) | |
|---|---|
| Demographics | |
| Age (years) | 66 (57–75) |
| Male gender | 14 (66.6%) |
| Body Mass Index (kg/m2) | 25.4 (20.4–27.5) |
| Comorbidities | |
| Chronic alcoholism | 7 (33.3%) |
| Diabetes | 3 (14.3%) |
| Corticosteroids ≥ 3 weeks in the last 2 months | 2 (9.5%) |
| Cirrhosis | 1 (4.7%) |
| Cancer | 1 (4.7%) |
| Reason for ICU admission | |
| Medical emergency | 16 (80.0) |
| Surgical emergency or scheduled surgery | 5 (20.0) |
| SAPS II score at ICU admission | 55 (39–68) |
| Patient characteristics at inclusion | |
| Length of total hospital stay at inclusion (days) Π | 14 (11–18) |
| Length of ICU stay at inclusion (days) | 11 (9–15) |
| SOFA score at inclusion | 7 (3–6) |
| Mechanical ventilation | 21 (100%) |
| Septic shock Ψ | 14 (66.6%) |
| Number of Candida colonization sites at inclusion Φ | 3 (2–4) |
| Creatinine (μmol/L) | 54.0 (41.0–80.5) |
| Kaliemia (mmol/L) | 3.6 (3.3–4.3) |
| Diuresis (mL/24h) | 2015 (1400–2800) |
| Concomitant administration of nephrotoxic treatment Θ | 17 (80.1%) |
| L-AmB administration characteristics | |
| L-AmB dosage administrated (mg/kg) at Day 1 | 10 (9.5–10.1) |
| Total volume reconstituted (mL) at Day 1 | 463 (340–547) |
| Total volume infused (mL) at Day 1 | 416 (310–468) |
| L-AmB dosage administrated (mg/kg) at Day 8 | 10 (10.0–10.7) |
| Total volume reconstituted (mL) at Day 8 | 463 (337–502) |
| Total volume infused (mL) at Day 8 | 463 (337–502) |
Abbreviations: ICU, Intensive Care Unit; SAPS, Simplified Acute Physiology Score; SOFA; Sequential Organ Failure Assessment score
Π There was 10 patients previously hospitalized before ICU admission
Ψ All patients received antibiotic medication for suspicion of new ICU acquired sepsis at inclusion: ventilator associated pneumonia (n = 8); surgical site infection (n = 1), bacteraemia (n = 2), undetermined (n = 10)
Φ Candida colonization sites among lung (n = 15), gastrointestinal tract (n = 6), urine (n = 7), mouth/pharynx/anus (n = 15), surgical area (n = 4), other (n = 7).
Θ One patient may have more than one concomitant administration of nephrotoxic treatment: antibiotics (n = 19); antihypertensive (n = 8); iodine-containing contrast media (n = 3)