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. 2017 May 10;12:3617–3636. doi: 10.2147/IJN.S124661

Figure 5.

Figure 5

SIRT1 regulates the induction of inflammatory cytokine expression by metal nanoparticles in the supernatant of Raw264.7 cells.

Notes: (A–D) Inhibition of the expression of inflammatory cytokines by resveratrol. The expression of inflammatory cytokines in Raw264.7 cells incubated with resveratrol (10 μM) for 12 h prior to stimulation with TiPs (100 μg/mL) or CoPs (100 μg/mL) for another 24 h. EX527 (5 μM) was used to reverse the effects of resveratrol. *P<0.05, **P<0.05, ***P<0.001. (E–H) Inhibition of the expression of inflammatory cytokines by SIRT1 overexpression. Control cells and SIRT1-overexpressing cells were stimulated with TiPs (100 μg/mL) or CoPs (100 μg/mL) for 24 h. *P<0.05, **P<0.05, ***P<0.001. The data of all the experiments are represented as the mean ± SEM from three independent experiments.

Abbreviations: SIRT1, Sirtuin 1; TiPs, TiAl6V4 particles; CoPs, CoCrMo particles; SEM, standard error of the mean; Res, resveratrol; LV-CON, lentivirus control.