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. 2017 May 10;12:3617–3636. doi: 10.2147/IJN.S124661

Figure 9.

Figure 9

NF-κB inhibitor suppresses metal nanoparticle-induced inflammatory responses in macrophages.

Notes: (A–D) The expression of inflammatory cytokines in the supernatant of Raw264.7 cells after pretreatment with BAY-11-7082 (10 μM) for 8 h prior to stimulation with TiPs (100 μg/mL) or CoPs (100 μg/mL) for another 24 h. The cytokine concentrations were quantified by ELISA. *P<0.05, **P<0.01, ***P<0.001. The data of all the experiments are represented as the mean ± SEM from three independent experiments.

Abbreviations: NF-κB, nuclear factor kappa B; TiPs, TiAl6V4 particles; CoPs, CoCrMo particles; SEM, standard error of the mean; ELISA, enzyme-linked immunosorbent assay; IL, interleukin; TNF, tumor necrosis factor.