Figure 4.

Mean release/dissolution profile versus time of RAV in aqueous buffer at 37°C in vitro, as SEDDS formulation (F5, mean diameter of nanoemulsion: 187 nm) or as free powder.

Notes: External dissolution medium I is PBS (pH 6.8) and medium II is PBS (pH 6.8) plus 5% (v/v) of surfactant (sink condition). Mean ± standard deviation data for the percentage cumulative amount of RAV released in vitro. The insert graph represent the first timepoints.

Abbreviations: PBS, phosphate-buffered saline; RAV, ravuconazole; SEDDS, self-emulsifying drug delivery system.