Table 3.
Effects of RAV incorporation on the physicochemical properties of SEDDS with 70% Miglyol
| Formulation | RAV, mg/mL | Epikuron, % | Labrasol, % | Ethanol, % | Mean diameter, nm$ | Mean PdI, n=3 | Zeta potential, mVa |
|---|---|---|---|---|---|---|---|
| F4 | 0 | 15 | 15 | 0 | 187.5±3.1 | 0.248 | −48.9±2.9 |
| 6 | 189.9±3.2 | 0.253 | −48.3±0.7 | ||||
| 8 | 189.9±2.3 | 0.249 | −47.4±0.5 | ||||
| 10 | Ppt | Ppt | ND | ||||
| F5 | 0 | 15 | 10 | 5 | 201.0±9.3 | 0.383 | −57.6±0.9 |
| 6 | 195.4±2.4 | 0.265 | −50.6±3.2# | ||||
| 10 | 197.5±6.9 | 0.295 | −50.0±3.5# | ||||
| 12 | Ppt | Ppt | ND |
Notes:
$
SEDDS emulsified in Milli-Q water at 37°C (1: 200 v/v);
a
Emulsions were further diluted 100-fold in Milli-Q water. Data are expressed as mean ± standard deviation (n=3); Ppt, drug precipitation.
#
Statistically significant compared to blank SEDDS.
Abbreviations: ND, not determined; PdI, polydispersity index; RAV, ravuconazole; SEDDS, self-emulsifying drug delivery system; Ppt, precipitate.