Figure 1.

The analysis of metabolites using metabolomics is a powerful technology that can inform and provide resolution to other “omic” technologies including genomics, transcriptomics, proteomics, and underlying phenotype. The main goal of broad‐based unbiased surveying using “omics” is to yield insight into mechanism underlying phenotype. This information then provides a rich data set to mine for new therapeutic targets and biomarkers of disease progression or treatment. Metabolites are uniquely positioned to enhance this inquiry because they are well annotated and function is directly related to gene expression. Using cross‐omic approaches with the adoption of metabolomics has been successful at narrowing focus and providing actionable hypotheses therefore, expanding the use of this technology will undoubtedly provide resolution.