Table 1.
Core facilities and other research resources provided by 60 CTSAs.
| Facilities and Services for Key Functions |
|---|
| Translational technologies |
| Amino acid analysis |
| Animal resources support, behavior, surgery, pathology, imaging, physiology, radiation therapy, target identification, model development, embryo preservation |
| Behavioral phenotyping, neuroscience core |
| Biophysical analysis |
| Biorepository, human tissue and fluid specimens, animal, microbiological |
| Body composition |
| Bone studies |
| Cell manufacture, study, biosurgery |
| cGMP facilities |
| Confocal microscopy |
| Cryopreservation of embryos, IVF |
| Cyclotron |
| Cytokine analysis |
| Device development |
| DNA analysis, sequencing, PCR |
| Drosophila |
| Electron microscopy |
| Electrophysiology core |
| Embryonic stem cells |
| Epigenomics |
| Fabrication, engineering, 3‐D printing |
| Flow cytometry |
| Gene therapy |
| Genomics core |
| High throughput screening (small molecules, RNAi, drug libraries) |
| High pressure liquid chromatography |
| Imaging cores |
| Immunology core |
| Intracytoplasmic sperm injection, in vitro fertilization |
| Mass spectrometry |
| Monoclonal antibody |
| Mouse core |
| Mutational analysis |
| Nanotechnology |
| Peptide and proteomics |
| Pharmaceutical core |
| Phenotyping |
| Pulmonary core |
| RNA expression, RNAi assays |
| Structural biology |
| Synchrotron |
| Synthetic chemistry |
| Therapeutic manufacture |
| Tissue bank |
| Toxicology |
| Transgene research |
| Vaccine core |
| Vector production |
| Virology |
| Xenografting |
| X‐ray diffraction crystallography |
| Zebrafish |
| Biomedical informatics |
| Application hosting, training |
| Behavioral data analysis |
| Biospecimen locator |
| Budget development support systems |
| Classification, language, ontology |
| Clinical data capture |
| Cohort/usergroup/data source identification |
| Communication tools, research, point of care |
| Computational biology |
| Computer facility, equipment, software packages |
| Crowd sourcing |
| CTSpedia |
| Customized software |
| Data acquisition, entry, analysis, management, quality control, sharing, transformation |
| Database development |
| Drug discovery |
| Feasibility, recruitment, |
| Genetic information sharing |
| Genomics analysis, genotype, array, sequencing |
| Geographic coding |
| Honest broker |
| Informatics for integrating biology and bedside |
| Image repository |
| Interfaces, internet applications |
| Motif finding |
| Novel analysis techniques |
| Privacy, security, HIPAA compliance |
| Proteomics |
| Registration for trials: ResearchMatch, others |
| Research Electronic Data Capture (REDCap) |
| RNA expression analysis |
| Sharing tools and consultation |
| Small molecule core analysis |
| Specialized (immuno, imaging) |
| Statistical packages |
| Supercomputing, cloud computing, warehousing, archiving, networks |
| Pilot funding |
| CTSA pilots |
| Institutional pilots |
| NIH institutional and center funding |
| Trainee and Scholar program |
| Other Federal agencies |
| Industry partners, private, not for profit |
| Regulatory knowledge |
| Advertisement, publicity, promotion |
| Adverse event reporting (AE, SAE) |
| Auditing, compliance measures |
| Budget review and development, training in good clinical practice and standard operating procedures |
| Clinical study monitoring |
| Clinical trials registry |
| http://www.ClinicalTrials.gov |
| Collaboration support, team building |
| Communication tool generation; newsletters, posters, fliers, mixed media, video, audio |
| Conflicts of interest management |
| Conflicts resolution |
| Contracts |
| Cost accounting, financial management, medical |
| coverage |
| Case report form prototypes |
| Data and Safety Monitoring Board |
| Document storage |
| Electronic forms processing |
| Emergency use of investigational drugs |
| Environmental health and safety |
| FDA guidance, IND, IDE support, management, reporting, meeting, communication |
| HIPAA compliance, IACUC, training programs in Responsible Conduct of Research, HSP |
| Informed consent document preparation |
| IRB prereview, review, waivers, agreements, triage |
| Legal advice |
| Office of research services |
| Protocol development team, studios, navigator, concierge |
| Protocol preparation, special cases, language |
| Public private partnership support |
| Recruitment and retention |
| Sponsored project handbook |
| Unanticipated risk evaluation |
| Workshop support |
| Biostatistics, epidemiology, research design, and ethics |
| Abstract, poster, table, figure, report, review assistance, manuscript preparation assistance |
| Adaptive (alternative) trial design, statistical models Bayesian analysis |
| Biostatistical team building |
| Comparative effectiveness research CTSpedia |
| Data analysis, reporting, coordination, mining |
| Detailed questionnaire preparation and review |
| Dose finding study methodology |
| Epidemiology assessment of risks, benefits, adherence |
| Ethics and genetics, team participation, cultures, communities |
| Ethics consultation, special topics |
| Gene environment interactions |
| Grant application support |
| Health services analysis |
| IRB application support |
| Multicenter coordination |
| Mu‐Stat and other special statistical analytic tools, outliers and distributional problems, missing data, model‐based methods, etc. |
| Randomization, blinding |
| Special assessments: quality of life, sample size, genetics |
| Study design |
| Participant and clinical interaction resources |
| Access, e‐application, e‐case report form completion, e‐tracking and reporting, |
| Calendar and scheduling of research‐related activities, meetings, reporting timelines |
| Case report form development, reporting compliance |
| Communication |
| Compliance with protocol, quality assurance, monitoring |
| Coordinator support, handbook, training |
| Cost recovery planning |
| Exercise and other functional testing facilities |
| Good Clinical Practice performance with standard operating procedures Standard |
| Operating Procedures, training, guidance |
| Diet, nutrition, energy consumption, body composition, metabolic kitchen, menus, special measurements |
| Phase I program |
| Phenotyping |
| Research nurse |
| Research Pharmacy |
| Research subject advocate |
| Review, reporting, oversight |
| Sleep study equipment, monitoring, testing |
| Community engagement |
| Adult literacy assessment, support |
| Community‐based consultation, advisory board, collaboration |
| Community‐wide IRB |
| Cultural competency training |
| Open forum to discuss research proposals, elicit suggestions |
| Public database |
| Relationships, trust, cultural advisor program |
| Research participation |
| Translation into community setting |