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. Author manuscript; available in PMC: 2017 May 22.
Published in final edited form as: Int J Nanotechnol Nanomed. 2016 Oct 30;1(1):http://www.opastonline.com/wp-content/uploads/2016/10/nanoparticles-for-effective-combination-therapy-of-cancer-ijnn-16-003.pdf.

Figure 2.

Figure 2

Nanoparticle based combinations therapy. A) Monotherapy versus dual therapy, and sequential administration versus simultaneous administration. B) A schematic representation of cocktail and nanocarrier approaches for combination drug therapy (hypothetical case study shown). The in vitro and then in vivo fixed molar ratio (synergistic effect) can be translated from in vitro assay using nanoparticle approach strategy versus cocktail approach. C) Hypothetical results of a standard clinical trials of two treatments using dendrimers as nanocarrier. Images reproduced with permission from Mignani et. al. [21].