Table 3B.
Findings obtained in previous studies on DMN in resting state fMRI in the comparison between patients groups (DLB, PD, and PSP) and healthy control group
| Groups | Authors | Results | Extra DMN regions | Method |
|---|---|---|---|---|
| DLB | Franciotti et al135 | Increased activity in PCC compared with AD | No | ICA |
| Galvin et al136 | Increased FC between PCC, DAN, and putamen. Decreased FC between PCC, DMN regions, and visual cortices | Yes | Seed | |
| Kenny et al137 | Increased FC between the right PCC and other brain areas | Yes | Seed | |
| PD | Gorges et al142 | Increased FC between bilateral hippocampus. Decreased FC between MPFC and PCC | No | Seed |
| Krajcovicova et al141 | Increased FC between PCC and DMN areas | No | ICA | |
| Franciotti et al103 | Increased FC in PD with visual hallucinations and reduced PD without visual hallucinations | No | ICA | |
| Yao et al139 | Increased FC between DMN areas in PD with visual hallucination and decreased FC in PD without hallucinations | Yes | ICA | |
| Baggio et al143 | Increased FC between DMN and lateral occipitoparietal regions | Yes | ICA | |
| Rektorova et al144 | Increased FC in DAN | Yes | ICA | |
| Shine et al140 | Increased FC between DMN and primary visual system | Yes | ICA | |
| Tessitore et al133 | Decreased FC of the right MTL and bilateral IPL | No | ICA | |
| Seibert et al206 | Decreased FC in bilateral prefrontal regions | No | Seed | |
| Olde Dubbelink et al207 | Decreased FC between multiple brain regions, especially in posterior parts of the brain | Yes | ICA | |
| Szewczyk-Krolikowski et al134 | Decreased FC in the BGN | Yes | ICA | |
| PSP | Whitwell et al159 | Decreased FC in premotor cortex, PFC, temporal lobe, thalamus, and striatum | Yes | ICA |
| MSA | Franciotti et al103 | Decreased FC in superior and medial frontal areas | No | ICA |
Note: The use of the seed-based analysis or the data-driven ICA (method) and the inclusion, in analysis, of regions not considered as part of DMN (extra DMN) are also indicated.
Abbreviations: DMN, default mode network; fMRI, functional magnetic resonance imaging; DLB, dementia with Lewy bodies; PD, Parkinson’s disease; PSP, progressive supranuclear palsy; PCC, posterior cingulate cortex; AD, Alzheimer’s disease; ICA, independent component analysis; FC, functional connectivity; DAN, dorsal attention network; MPFC, medial prefrontal cortex; IPL, inferior parietal lobe; BGN, basal ganglia network; PFC, prefrontal cortex; MTL, middle temporal lobe.