Table S3.

Time-to-first exacerbation for budesonide/formoterol and formoterol in all patients and according to COPD disease severity group

Study month	Time-to-first exacerbation
	All patients, n=2,345		Disease severity
		P-value	Moderate COPD, n=408	Severe COPD, n=1,325	Very severe COPD, n=612
1	0.528 (0.385, 0.723)	<0.0001	0.513 (0.207, 1.272)	0.531 (0.340, 0.830)*	0.525 (0.316, 0.873)*
2	0.532 (0.420, 0.673)	<0.0001	0.601 (0.303, 1.194)	0.519 (0.373, 0.722)***	0.519 (0.352, 0.765)**
3	0.586 (0.478, 0.718)	<0.0001	0.615 (0.347, 1.089)	0.547 (0.412, 0.726)***	0.625 (0.443, 0.881)*
4	0.599 (0.499, 0.719)	<0.0001	0.578 (0.349, 0.957)*	0.613 (0.476, 0.790)**	0.575 (0.422, 0.782)**
5	0.639 (0.540, 0.758)	<0.0001	0.603 (0.374, 0.974)*	0.641 (0.508, 0.810)**	0.632 (0.474, 0.843)**
6	0.687 (0.586, 0.805)	<0.0001	0.694 (0.447, 1.077)	0.660 (0.531, 0.822)**	0.705 (0.539, 0.923)*
7	0.736 (0.632, 0.857)	<0.0001	0.740 (0.483, 1.134)	0.699 (0.567, 0.862)**	0.770 (0.593, 0.998)*
8	0.772 (0.665, 0.895)	0.0006	0.767 (0.504, 1.165)	0.736 (0.600, 0.903)**	0.806 (0.625, 1.040)
9	0.794 (0.688, 0.917)	0.0017	0.777 (0.516, 1.170)	0.769 (0.632, 0.935)**	0.816 (0.637, 1.046)
10	0.778 (0.676, 0.897)	0.0005	0.710 (0.475, 1.061)	0.754 (0.622, 0.913)**	0.823 (0.643, 1.053)
11	0.788 (0.685, 0.906)	0.0008	0.745 (0.501, 1.107)	0.763 (0.632, 0.921)**	0.823 (0.644, 1.051)
12	0.790 (0.688, 0.907)	0.0008	0.745 (0.501, 1.107)	0.765 (0.635, 0.921)**	0.824 (0.646, 1.050)

Notes: Data are presented as reduction in time-to-first exacerbation and 95% confidence intervals.

^*P<0.05;

^**P<0.005;

^***P<0.0001.