Table 2.
Demographic and pre-index clinical characteristics after matching
| Characteristica | RCI vs IVIg
|
RCI vs rituximab
|
RCI vs IVIg+rituximab
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| RCI (N=130) | IVIg (N=390) | STDdiff (%) | RCI (N=110) | Rituximab (N=330) | STDdiff (%) | RCI (N=87) | IVIg+ rituximab (N=87) | STDdiff (%) | |
| Age (at index date), mean (SD) | 52.6 (11.81) | 52.7 (14.15) | 1.4 | 52.9 (12.26) | 52.1 (14.00) | 6.1 | 50.8 (11.91) | 50.3 (13.68) | 4.4 |
| Female, n (%) | 87 (66.9) | 257 (65.9) | 2.2 | 75 (68.2) | 227 (68.8) | 1.3 | 57 (65.5) | 54 (62.1) | 7.1 |
| Indication of cancer, n (%) | 21 (16.2) | 67 (17.2) | 2.8 | 21 (19.1) | 65 (19.7) | 1.5 | 19 (21.8) | 18 (20.7) | 2.8 |
| Prior DM/PM treatment, n (%) | 119 (91.5) | 347 (89.0) | 8.6 | 102 (92.7) | 293 (88.8) | 13.6 | 80 (92.0) | 79 (90.8) | 4.1 |
| Prior corticosteroids (prednisone or methylprednisolone), n (%) | 108 (83.1) | 329 (84.4) | 3.5 | 99 (90.0) | 287 (87.0) | 9.5 | 74 (85.1) | 75 (86.2) | 3.3 |
| Prior azathioprine, n (%) | 36 (27.7) | 92 (23.6) | 9.4 | 25 (22.7) | 62 (18.8) | 9.7 | 25 (28.7) | 23 (26.4) | 5.1 |
| Prior methotrexate, n (%) | 52 (40.0) | 150 (38.5) | 3.1 | 46 (41.8) | 135 (40.9) | 1.8 | 32 (36.8) | 33 (37.9) | 2.4 |
| Prior MMF, n (%) | 28 (21.5) | 86 (22.1) | 1.2 | 24 (21.8) | 66 (20.0) | 4.5 | 22 (25.3) | 20 (23.0) | 5.3 |
| Deyo’s adapted CCI score, mean (SD) | 1.9 (1.59) | 1.8 (1.73) | 4.2 | 2.0 (1.66) | 2.0 (1.78) | 2.1 | 1.9 (1.74) | 1.8 (1.49) | 8.5 |
| Elixhauser Comorbidity Index score (≥2), n (%) | 84 (64.6) | 253 (64.9) | 0.5 | 69 (62.7) | 198 (60.0) | 5.6 | 62 (71.3) | 62 (71.3) | 0.0 |
| Chronic Disease Score, mean (SD) | 7.5 (3.78) | 7.2 (4.06) | 8.0 | 7.2 (3.72) | 7.1 (4.14) | 2.5 | 7.2 (4.02) | 7.0 (4.26) | 3.3 |
| Pre-index number of hospitalizations, mean (SD) | 2.5 (8.40) | 2.5 (4.88) | 0.2 | 2.9 (9.07) | 3.2 (6.83) | 3.5 | 3.5 (10.10) | 3.4 (7.08) | 1.1 |
| Pre-index total costs (excluding | $36,320 | $35,203 | 2.4 | $33,487 | $34,524 | 2.3 | $43,690 | $43,351 | 0.7 |
| DM/PM medication costs), mean (SD) | ($46,852) | ($47,225) | ($45,898) | ($43,409) | ($54,525) | ($44,265) | |||
Note:
a
All variables used in the propensity score matching used to match patients receiving RCI to those not receiving RCI.
Abbreviations: CCI, Charlson Comorbidity Index; DM, dermatomyositis; IVIg, intravenous immunoglobulin; MMF, mycophenolate mofetil; PM, polymyositis; RCI, repository corticotropin injection SD, standard deviation; STDiff, standard difference.