Table 1.
Characteristics of enrolled patients treated with Met-IR and Met-XR
| Characteristics | Met-IR | Met-XR | Met-IR | Met-XR | Met-IR | Met-XR |
|---|---|---|---|---|---|---|
|
|
|
|
||||
| Baseline | 3 months | 6 months | ||||
| n | 125 | 128 | 119 | 124 | 115 | 120 |
| Sex (M/F) | 60/65 | 62/66 | 57/62 | 61/63 | 56/59 | 59/61 |
| Age (years) | 55.8±10.7 | 56.5±11.3 | 55.8±10.7 | 56.5±11.3 | 55.8±10.7 | 56.5±11.3 |
| Height (m) | 1.67±0.05 | 1.66±0.04 | 1.67±0.05 | 1.66±0.04 | 1.67±0.05 | 1.66±0.04 |
| Weight (kg) | 76.1±5.9 | 75.8±5.6 | 74.9±5.1 | 74.1±4.8 | 73.4±4.8* | 72.2±4.2* |
| BMI (kg/m2) | 27.3±2.1 | 27.5±2.4 | 26.8±1.7 | 26.9±1.8 | 26.4±1.4* | 26.2±1.2* |
| Abdominal circ (cm) | 93.5±3.4 | 92.8±3.1 | 91.8±3.1 | 92.0±3.2 | 90.2±2.7* | 90.4±2.9* |
| Waist circ (cm) | 90.6±4.1 | 91.2±4.8 | 88.5±3.7 | 89.7±4.2 | 88.4±3.6 | 89.2±3.8 |
| Hip circ (cm) | 100.7±6.4 | 99.6±5.8 | 98.4±5.9 | 97.5±5.4 | 98.6±6.0 | 97.1±5.1 |
| HbA1c (%) | 7.7±0.6 | 7.6±0.5 | 7.3±0.4* | 7.1±0.3* | 7.3±0.4* | 6.8±0.3**,*** |
| FPG (mg/dL) | 144.8±18.6 | 146.3±19.5 | 138.5±16.4 | 130.9±14.1* | 132.8±14.4* | 122.3±11.5**,*** |
| PPG (mg/dL) | 182.4±21.5 | 184.7±23.2 | 171.5±18.4* | 168.7±17.2* | 165.2±15.3* | 151.5±12.4**,*** |
| FPI (µU/mL) | 18.3±5.1 | 18.9±5.6 | 16.9±4.7 | 17.4±4.9 | 17.2±5.0* | 16.8±4.5* |
| HOMA-IR index | 6.5±2.9 | 6.8±3.2 | 5.7±2.2 | 5.6±2.1* | 5.5±2.0* | 5.0±1.7**,*** |
| TC (mg/dL) | 185.4±30.6 | 188.7±33.9 | 179.8±27.1 | 177.7±26.4 | 176.3±22.6 | 168.1±20.2*,*** |
| LDL-C (mg/dL) | 121.9±17.1 | 125.2±19.3 | 117.6±15.8 | 120.3±16.7 | 113.5±13.4 | 106.4±11.4*,*** |
| HDL-C (mg/dL) | 42.4±6.5 | 41.8±5.7 | 42.1±6.3 | 42.1±5.9 | 43.1±6.9 | 43.5±7.1 |
| Tg (mg/dL) | 105.2±45.8 | 108.4±47.2 | 100.4±43.2 | 101.6±43.9 | 98.6±40.5 | 90.1±38.6* |
| Hs-CRP (mg/L) | 2.2±1.1 | 2.4±1.3 | 2.0±1.0 | 1.9±1.0* | 2.0±1.0 | 1.7±0.8*,*** |
Notes: Data are expressed as mean ± standard deviation.
*
P<0.05 vs baseline.
**
P<0.01 vs baseline.
***
P<0.05 vs Met-IR.
Abbreviations: Met-IR, metformin immediate release; Met-XR, metformin extended release; M, male; F, female; BMI, body mass index; circ, circumference; HbA1c, glycated hemoglobin; FPG, fasting plasma glucose; PPG, postprandial plasma glucose; FPI, fasting plasma insulin; HOMA-IR, homeostasis model assessment insulin resistance index; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; Tg, triglyceride; Hs-CRP, high-sensitivity C-reactive protein.