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. 2017 May 1;10:121. doi: 10.3389/fnmol.2017.00121

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Copyright © 2017 Ding, Weng, Fan, Cao and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impaired motor coordination in Ankfy1/+ mice. (A) Photographs of Ankfy1/+ mice showing the clasping, spastic paralysis and kyphosis phenotypes, which were not observed in the WT mice. (B) Significant differences in body weights were observed between the WT (n = 10) and Ankfy1/+ mice (n = 9; ***p < 0.001). (C) Stride length, (D) front/hind footprint overlap and (E) foot dragging were evaluated from 4 weeks to 36 weeks of age, and phenotype severity was detected from 8 weeks to 36 weeks of age (n = 8–10, **p < 0.05, ***p < 0.001). (F) Differences in accelerating rotarod performance observed between WT (n = 11) and Ankfy1/+ mice (n = 13) were statistically significant (*p < 0.05, ***p < 0.001). The data represent means ± SEM.