Figure 3.

POMC IR KO mice have increased fatty acid utilization rates. A: Energy expenditure of AgRP IR KO, POMC IR KO mice, and their respective WT littermates, as measured by total VO₂ consumption in metabolic chambers via indirect calorimetry. B: Average VO₂ between groups. C: RER measurement. D: Average RER. E: Locomotor activity in metabolic chambers. F: Rectal temperature (°C) of mice during cold tolerance test at 4°C for 2 h. n ≥6 per group. Values are mean ± SEM. *P < 0.05 compared with respective WT.