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. 2017 May 22;12(5):e0178247. doi: 10.1371/journal.pone.0178247

Fig 1. Differences in baseline and post-exercise electrocorticogram activity in APP/PS1 mice.

Fig 1

A, A bout of moderate exercise specifically increases theta frequencies in the elecorticogram (ECG) of wild type mice (T = -5,72; df = 33; *p<0.05; n = 9). B, No changes are seen in APP/PS1 mice (n = 9) after exercise. Pre: 5 min ECG recordings before exercise; Post: 5 min ECG recordings after exercise. Results are the mean of pooling together ECG recordings performed by each mouse after 15 and 30 min of exercise in independent days. C, Electrophysiological simultaneous recordings of the ECG (upper record) and of the hippocampal CA1 region (lower record) when theta rhythm was evoked by sensory stimulation (Raw Data). Dashed vertical lines indicate the correspondence of positive peaks of hippocampal theta rhythm with positive peaks in the ECG. Lower plot shows the CC of the hippocampal theta rhythm respect to ECG activity after digital filtering between 4–8 Hz. Periodic peaks implies phase-locking of both theta rhythms. D, Baseline ECG recordings in wild type and APP/PS1 mice show differences in various frequency bands (Delta: t = 4,8; df = 68,56; Beta: t = -3,76; df = 72; Gamma: t = -2,04; df = 72; *p<0.05; ***p<0.001; n = 9 per group). Results shown are mean ± S.E.M.