Fig 2. Y maze performance after exercise.

A, Both control and APP/PS1 mice performed similar in the acquisition phase of the Y maze before exercise, showing a similar rate of entries in each of the three arms of the maze. B, However, while control mice significantly improved their performance after exercise in the Y maze, as determined by increased preference for the novel arm, APP/PS1 did not. C, Improved performance was corroborated by increased time spent in the novel arm only in control mice. Sed: sedentary; Exe: exercised (n = 6 per group; one-way ANOVA (exercise x genotype interaction): F = 28.78, df = 17; ***p<0.0001 control vs APP/PS1; post-hoc t-test: *p<0.05 vs sedentary).