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. Author manuscript; available in PMC: 2017 Oct 14.
Published in final edited form as: RSC Adv. 2016 Oct 14;6(102):100652–100663. doi: 10.1039/C6RA17459K

Figure 1. HJC0123 inhibits human and rat hepatic stellate cells proliferation.

Figure 1

(A) Interactions of HJC0123 with the residues of STAT3. HJC0123 is shown in small sticks and in pink color with the chemical structure depicted. Hydrogen bonds are indicated by dashed lines. LX-2 cells (B), HSC-T6 cells (C) and C3A (D) cells were treated with incremental concentrations of HJC0123 for 48 hours, and cell viability was determined using Alamar Blue assay. Similarly, LX-2 cells were treated with increasing concentrations of commercially available STAT3 inhibitors (E) FLLL32 (left) and S31-201 (right). Dose response curves were calculated using GraphPad Prism 6.0. The results are representative of at least three independent experiments.