FIG. 3.

Enhanced insulin-stimulated 2-deoxyglucose uptake into isolated soleus muscles of high-fat-fed mckPten^−/− mice. (A and B) Soleus or (C) EDL muscles isolated from 6-month-old mice fed (A) chow or (B and C) high fat were incubated with or without 2 mU of insulin per ml for 30 min. 2-Deoxyglucose uptake was measured over 20 min. Results are the means ± standard errors from four independent experiments. All values are normalized relative to the lowest 2-deoxyglucose uptake value in order to express all values as greater than one.