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. 2005 Feb;25(3):1135–1145. doi: 10.1128/MCB.25.3.1135-1145.2005

FIG. 6.

FIG. 6.

Continued protection from insulin resistance and diabetes in older mckPten−/− mice on prolonged high-fat feeding. (A) Insulin tolerance tests were performed on 15-month-old mckPten+/− and mckPten−/− mice on a chow or high-fat diet as described in Materials and Methods. (B) Glucose tolerance tests were performed on 15-month-old mckPten+/− and mckPten−/− mice on a chow or high-fat diet as described in Materials and Methods. * and **, P < 0.01 and P < 0.1, respectively, comparing mckPten+/− and mckPten−/− mice on a high-fat diet. All results are expressed as means ± standard errors of the means from at least 10 animals of each genotype.