VT images for participant 2 (test scan), co-registered to the corresponding T1-weighted MRI image. The images were produced by voxelwise Logan’s graphical analysis with ppIF (A – top row), and voxelwise (exponential) SA (B, bottom row). The dynamic data were smoothed (isotropic filter with 2.0 mm FWHM) prior to Logan’s graphical analysis. Note the high binding in temporal regions, and the low binding in the cerebellum. Images are shown in radiological orientation (left on right). The colour bar depicts VT. SA – spectral analysis, VT – volume-of-distribution. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article).