Database	Date of Search	Search terms
ClinicalTrials.gov	31 July 2015	#1 “sickle cell” OR “haemoglobin S disease” OR “haemoglobin S disorder” OR “HbS disease” #2 “folic acid” OR folate OR “vitamin B9” OR “vitamin B-9” OR metafolin OR levomefolate OR folvite OR folacin OR 5-methyltetrahydrofolate OR 5-methylTHF #1 AND #2 Results: 9