Table 1.
Baseline characteristics of the incident atrial fibrillation patients
| Overall (N=3491) | 2000–2003 (N=808) | 2004–2007 (N=944) | 2008–2010 (N=769) | 2011–2013 (N=970) | P-value for trend | |
|---|---|---|---|---|---|---|
| Age, mean (SD) | 71.0 (14.9) | 71.1 (14.9) | 71.0 (15.1) | 70.5 (14.8) | 71.4 (14.7) | 0.671 |
| Male | 1901 (54.5) | 420 (52.0) | 491 (52.0) | 435 (56.6) | 555 (57.2) | 0.007 |
| Body mass index, kg/m2 | 0.010 | |||||
| <25 | 985 (28.2) | 226 (28.0) | 295 (31.3) | 211 (27.4) | 253 (26.1) | |
| 25 to <30 | 1153 (33.1) | 283 (35.0) | 312 (33.1) | 253 (32.9) | 305 (31.5) | |
| ≥ 30 | 1350 (38.7) | 299 (37.0) | 335 (35.6) | 305 (39.7) | 411 (42.4) | |
| Smoking status | 0.093 | |||||
| Current | 372 (10.7) | 90 (11.1) | 92 (9.8) | 87 (11.3) | 103 (10.6) | |
| Former | 1428 (40.9) | 317 (39.2) | 374 (39.6) | 327 (42.5) | 410 (42.3) | |
| Never | 1691 (48.4) | 401 (49.6) | 478 (50.6) | 355 (46.2) | 457 (47.1) | |
| Hypertension | 2302 (65.9) | 473 (58.5) | 623 (66.0) | 536 (69.7) | 670 (69.1) | <0.001 |
| Myocardial infarction | 331 (9.5) | 74 (9.2) | 79 (8.4) | 70 (9.1) | 108 (11.1) | 0.103 |
| Diabetes | 686 (19.7) | 117 (14.5) | 172 (18.2) | 179 (23.3) | 218 (22.5) | <0.001 |
| Chronic pulmonary disease | 430 (12.3) | 129 (16.0) | 107 (11.3) | 78 (10.1) | 116 (12.0) | 0.015 |
| Peripheral vascular disease | 254 (7.3) | 45 (5.6) | 71 (7.5) | 58 (7.5) | 80 (8.3) | 0.045 |
| Dementia | 182 (5.2) | 36 (4.5) | 43 (4.6) | 54 (7.0) | 49 (5.1) | 0.253 |
| Malignancy | 671 (19.2) | 167 (20.7) | 153 (16.2) | 159 (20.7) | 192 (19.8) | 0.686 |
| Metastatic solid tumor | 178 (5.1) | 40 (5.0) | 44 (4.7) | 51 (6.6) | 43 (4.4) | 0.996 |
| Renal disease | 194 (5.6) | 30 (3.7) | 33 (3.5) | 44 (5.7) | 87 (9.0) | <0.001 |
| eGFR, mean (SD), mL/min per 1.73 m2* | 65.9 (26.2) | 59.0 (19.9) | 63.0 (23.4) | 70.6 (29.0) | 70.6 (29.1) | <0.001 |
| Rheumatologic disease | 166 (4.8) | 40 (5.0) | 42 (4.5) | 35 (4.6) | 49 (5.1) | 0.854 |
| Ischemic stroke or TIA | 404 (11.6) | 90 (11.1) | 110 (11.7) | 89 (11.6) | 115 (11.9) | 0.672 |
| Liver disease | 65 (1.9) | 9 (1.1) | 20 (2.1) | 13 (1.7) | 23 (2.4) | 0.104 |
| CHA2DS2-VASc, mean (SD) | 2.9 (1.8) | 2.8 (1.8) | 2.9 (1.8) | 2.9 (1.8) | 3.0 (1.8) | 0.079 |
All results are reported as n (%) unless otherwise specified.
TIA, transient ischemic attack; eGFR, estimated glomerular filtration rate.
*
Among 3261 patients with eGFR measured within ±90 days of index.