FIG. 4.
Dpax-induced wing blisters can be rescued by components in the Rho pathway, including Dlimk and its downstream targets. (A and D) Overexpression of UAS-Dpax driven by en-GAL4 or 32B-GAL4 results in blistered wings (arrows). (B) Overexpression of UAS-Dlimk driven by en-GAL4 results in multiple defects in the posterior part of the wing (6). (C and F) Overexpression of Dlimk (C) or DSRF (F) rescues the Dpax-induced blistered-wing phenotype. (E) A mutation in cofilin (tsrko5633), the downstream target of LIMK, rescues the wing-blistering defect. Flies were maintained at 18°C.