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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Free Radic Biol Med. 2016 Nov 22;107:245–257. doi: 10.1016/j.freeradbiomed.2016.11.022

Table 1.

Inhibition of helicase-catalyzed unwinding by replication-blocking lesions.

Helicase Thymine Glyco Cyclopurine
RECQL1 ++++ (tr. str.)43 ++++ (tr. str.)41
WRN +++ (tr. str.)43 +++ (tr. str.)41
BLM ++++++ (tr. str.)43 ++++++ (tr. str.)41
FANCJ ++++++ (ntr. str.)43
+++++ (tr. str.)43 +++ (tr. str.)41
DDX11 (CHlR1) ND + (tr. str.)41
    Twinkle +++ (tr. str.)42 -42

++++++, Strong inhibition; +++, Modest (~2-fold) inhibition; −, no dectectable inhibition; ND, not determined;

tr. str., translocating strand inhibition; ntr. str., non-translocating strand inhibition