Table 5. Serial change in atheroma burden in patients receiving CER-001.
| IVUS measures | Baseline PAV <30% (n=74) | Baseline PAV ≥30% (n=202) | P value |
|---|---|---|---|
| Change in PAV (%) | 0.34±1.69 | −0.45±2.65 | 0.01 |
| Adjusted change in PAV (%)* | −0.07±0.42 | −0.28±0.49 | 0.03 |
| Change in EEM (mm3) | −14.1±30.6 | −5.6±27.0 | 0.02 |
| Change in lumen volume (mm3) | −11.96±25.3 | −1.74±21.8 | 0.001 |
| Any progression#, n (%) | 50 (67.5) | 92 (45.5) | 0.001 |
*, adjusted for baseline PAV, clinical characteristics (age, gender, body mass index, hypertension and hypercholesterolemia), medication use (statin, high-intensity statin and angiotensin converting enzyme inhibitor) and the degree of risk factor control (change in glycated hemoglobin, high-sensitivity c-reactive protein and diastolic blood pressure); #, change in PAV >0%. IVUS, intravascular ultrasound; EEM, external elastic membrane; PAV, percent atheroma volume.