Table 3.
Results of SUVR cutoff categorization (and 95% confidence intervals) of 18F-Florbetaben PET scans compared to histopathological determination of Aβ in the brain.
| Target region | Reference region | Sensitivity | Specificity | Accuracy |
|---|---|---|---|---|
| Compositea | GCER | 87 (75–95) | 88 (69–97) | 87 (78–94) |
| WCER | 92 (82–98) | 96 (80–100) | 94 (86–98) | |
| PONS | 92 (82–98) | 96 (80–100) | 94 (86–98) | |
| SWM | 94 (84–99) | 60 (39–79)b, c | 83 (73–91) | |
| Frontal cortex | GCER | 89 (75–97) | 72 (47–90) | 84 (72–92) |
| WCER | 97 (86–100) | 72 (47–90) | 89 (78–96) | |
| PONS | 92 (79–98) | 72 (47–90) | 86 (74–94) | |
| SWM | 95 (82–99) | 53 (28–77) | 82 (69–91) | |
| Posterior cingulate cortex | GCER | 86 (68–96) | 58 (37–77) | 73 (59–84) |
| WCER | 93 (77–99) | 58 (37–77) | 76 (63–87) | |
| PONS | 97 (83–100) | 62 (41–80) | 80 (67–90) | |
| SWM | 100 (88–100) | 24 (9–45) | 65 (51–77) |
a
Composite region = mean SUVR of 6 cortical regions (frontal, occipital, parietal, lateral temporal and posterior and anterior cingulate cortex regions).
b
Statistically significant differences with respect to WCER.
c
Statistically significant differences with respect to PONS.