Table 1.

Meaningful single-nucleotide polymorphisms (SNPs) associated with accelerated cognitive decline and the corresponding regression coefficients for the interaction effects. Minor allele frequency (MAF) is the frequency where the second most common allele occurs in a population

SNP	Chr	Gene	MAF	Coefficient	SE	F value	P value
rs17090219	18		0.093	5.15	0.93	30.54	9.48 × 10−8
rs3936289	3	ST6GAL1	0.256	3.34	0.64	26.83	4.92 × 10−7
rs56378310	13	RAB20	0.424	−2.98	0.60	24.40	1.52 × 10−6
rs192470679	13	PDS5B	0.300	2.89	0.59	24.36	1.55 × 10−6
rs11121365	1	SPSB1	0.062	5.76	1.18	24.00	1.92 × 10−6
rs2484	3	BDH1	0.095	4.53	0.94	23.03	2.83 × 10−6
rs10903488	10	ADARB2	0.083	4.58	0.96	22.80	3.24 × 10−6

NOTE. The SNPs mentioned in table have been reported to be related to Alzheimer's disease (AD) directly/indirectly. The regression coefficient, SE (standard error), and F-test statistic value are shown for the interaction effect of each of the SNPs and the AD diagnosis trajectory. A positive coefficient value implies that cognitive decline gets accelerated after AD conversion as the number of minor alleles of the corresponding SNP increases.