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SIZN1 may involve in EMT induction through GLI1 expression and BMP signaling. SIZN1 interacts with the receptor-regulated SMADs (SAMD1/2/3/5/8) to co-activate the signaling and recruit SMAD4. GLI1 expression is enhanced following SMAD4/SMAD3 binding to its regulatory region, and subsequently GLI1 induces the SNAIL expression
