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The mechanisms of heparin mediated c-Met signaling upregulation in HCC. Heparin activated c-Met receptor through receptor dimerization (a), recruited Gab1 and PI3K to the receptor (b) heparin-induced c-Met activation led to ERK1/2 activation (c), and EGR1 up-regulation (d), EGR1 activation caused induction in migration, invasion (e), heparin induced PTEN expression caused downregulation of Akt activation (f), Akt inhibition caused proliferation repression and cell cycle arrest (g)
