Figure 1.

Effect of the lack of Tyro3, Axl, or Mer on hemostasis. After 2-mm tail-tip transection, the cut end of the tail was immersed in saline at 37–C. Aliquots of saline solution containing blood were sampled every minute for 10 minutes and then every 5 minutes until 30 minutes. The amount of blood loss was determined by measurement of the hemoglobin content of the aliquots of blood collected in saline (mean ± SEM, n = 10). In WT mice, blood loss reached a plateau within 10 minutes, indicating cessation of bleeding. In contrast, Tyro3^–/–, Axl^–/–, and Mer^–/– mice had a tendency to repetitively rebleed after transient hemostasis.