Table 1.
Important potential transcriptional activators of upregulated and downregulated genes in CMs
| Term | Overlap | P-value | Adjusted P-value | Combined score | |
|---|---|---|---|---|---|
| TFS activating the expression of CM specific genes | ESRRB | 73 | 3.24E-54 | 2.01E-51 | 238.0692 |
| GATA4 | 46 | 5.51E-19 | 6.86E-17 | 75.45215 | |
| PPARG | 16 | 5.11E-13 | 1.91E-11 | 75.39176 | |
| TAF7L | 26 | 3.1E-13 | 1.29E-11 | 70.3822 | |
| NR0B1 | 41 | 5.25E-18 | 3.92E-16 | 68.08592 | |
| EP300 | 25 | 1.9E-11 | 4.44E-10 | 62.14964 | |
| NKX2–5 | 34 | 3.75E-14 | 1.75E-12 | 60.82659 | |
| ASH2L | 61 | 8.45E-21 | 1.58E-18 | 42.91397 | |
| E2F1 | 64 | 4.67E-18 | 3.92E-16 | 41.71403 | |
| BCL3 | 24 | 3.94E-12 | 1.22E-10 | 41.42514 | |
| TFs activating the expression of CF specific genes | RARG | 21 | 2.68E-16 | -2.45541 | 88.04412 |
| NRF2 | 30 | 1.50E-15 | -1.70414 | 58.16592 | |
| NFE2L2 | 30 | 1.50E-15 | -1.70414 | 58.16592 | |
| E2F1 | 64 | 3.31E-19 | -1.18513 | 50.43121 | |
| SOX17 | 37 | 1.15E-13 | -1.57483 | 46.92527 | |
| TCF3 | 40 | 5.29E-14 | -1.52041 | 46.47912 | |
| CLOCK | 16 | 9.67E-11 | -1.7818 | 41.08756 | |
| YAP1 | 42 | 1.04E-14 | -1.26895 | 40.86082 | |
| SOX2 | 42 | 2.45E-13 | -1.38276 | 40.14992 | |
| PPARG | 54 | 8.78E-16 | -1.06914 | 37.066 |