Table 3.
Candidate transcriptional activators for enhancing direct cardiac reprogramming and increasing the maturity of iCMs
| Proteins | UP | G-TF | CM-Net | Net-TF | Score |
|---|---|---|---|---|---|
| MEF2A | ✓ | ✓ | ✓ | ✓ | 4 |
| JUN | ✓ | ✓ | ✓ | 3 | |
| KAT2B | ✓ | ✓ | ✓ | 3 | |
| ATF3 | ✓ | ✓ | ✓ | 3 | |
| GABPA | ✓ | ✓ | ✓ | 3 | |
| MEF2C | ✓ | ✓ | ✓ | 3 | |
| GATA4 | ✓ | ✓ | ✓ | 3 | |
| PPARGC1A | ✓ | ✓ | 2 | ||
| TUBA4A | ✓ | ✓ | 2 | ||
| FHL2 | ✓ | ✓ | 2 | ||
| SLC8A1 | ✓ | ✓ | 2 | ||
| MXI1 | ✓ | ✓ | 2 | ||
| MITF | ✓ | ✓ | 2 | ||
| TAF1B | ✓ | ✓ | 2 | ||
| TBX5 | ✓ | ✓ | 2 |
UP: genes upregulated in CMs,
G-TF: transcriptional activators of the genes upregulated in CMs,
CM-Net: CM gene regulatory network
Net-TF: TFs activating the CM gene regulatory network
✓ indicates the presence of factors in following items: