Table 3.

Regression coefficients, standard errors, and model summary information (R²) for the age 16 alcohol use problems (AUP) parallel multiple mediator models

Predictor	Paths from PRS to personality dimensions				Paths from personality dimensions to AUP				R2
	Path	Coeff.	SE	P	Path	Coeff.	SE	p
Sensation seeking	a1	26.98	12.60	.03	b1	8 × 10-4	1 × 10-4	<.001	.11
Extraversion	a2	14.63	11.15	.19	b2	.002	2 × 10-4	<.001	.02
Agreeableness	a3	-10.85	7.79	.16	b3	-4 × 10-4	2 × 10-4	.09	.11
Negative emotionality	a4	3.09	8.74	.72	b4	9 × 10-4	2 × 10-4	<.001	.07
Conscientiousness	a5	-12.87	10.66	.23	b5	-9 × 10-4	2 × 10-4	<.001	.01
Openness/imagination	a6	-2.07	8.42	.81	b6	-6 × 10-4	2 × 10-4	.02	.06

Notes: Statistical covariates were included in all models but not presented in the tables. R² for paths from personality dimensions to AUP are the same as R² for paths from PRS to personality dimensions, as all pathways were simultaneously tested using the same model (Figure 1). PRS = polygenic risk scores at p = .05 threshold (number of genotyped single nucleotide polymorphisms = 17,008); coeff. = coefficient (unstandardized beta).