. 2017 May 22;7:2233. doi: 10.1038/s41598-017-02351-6

Table 1.

Serum, urine biochemistries and physiological parameters in CKD and control mice.

	Control		CKD
	Control		CKD-NP		CKD-HP
	C6	C12	A6	A12	A6P2	A6P4	A6P6
Body Weight (g)	24.7 ± 0.6	25.8 ± 0.9	18.0 ± 0.5*	15.6 ± 0.5*^#	16.4 ± 1.0*^#	14.5 ± 0.4*^#	16.0 ± 0.7*^#
Food Intake (g/day)	2.4 ± 0.4	2.2 ± 0.6	3.8 ± 0.8*	4.3 ± 1.2	2.9 ± 1.0*	3.4 ± 1.0	3.2 ± 1.3
Urine Volume (ml/day)	0.87 ± 0.31	0.83 ± 0.36	4.16 ± 1.19*	5.19 ± 0.59*	3.44 ± 0.98*	4.01 ± 1.89*	4.00 ± 1.47*
BUN (mg/dl)	32.0 ± 6.3	32.8 ± 4.3	125.1 ± 9.5*	159.9 ± 11.2*^#	85.2 ± 4.4*^#δ	75.6 ± 9.8*^#δ	70.3 ± 7.0*^#δ
Creatinine (mg/dl)	0.12 ± 0.03	0.10 ± 0.02	0.66 ± 0.04*	0.91 ± 0.11*^#	0.47 ± 0.06*^#δ	0.41 ± 0.05*^#δ	0.42 ± 0.06*^#δ
24 h CCr (ml/min/kg)	8.49 ± 1.46	12.29 ± 3.95	1.75 ± 0.49*	1.67 ± 0.08*	1.63 ± .047*	2.45 ± 1.48*	3.20 ± 1.09*
Calcium (mg/dl)	8.08 ± 0.59	8.21 ± 0.18	8.52 ± 0.79	9.14 ± 0.80	8.66 ± 0.91	8.13 ± 0.80	8.19 ± 1.18
Phosphorous (mg/dl)	8.01 ± 2.70	7.43 ± 1.67	9.47 ± 2.14	12.3 ± 2.40*	20.9 ± 1.90*^#δ	18.7 ± 4.55*^#δ	18.9 ± 3.44*^#δ
FEphos	0.10 ± 0.03	0.05 ± 0.02	0.25 ± 0.15	0.15 ± 0.04	0.71 ± 0.09*^#δ	0.72 ± 0.10*^#δ	0.83 ± 0.06*^#δ
ALP (IU/min)	275 ± 40	225 ± 39	789 ± 120*	645 ± 88*	1618 ± 324*^#	811 ± 186*	911 ± 222*
intact PTH (pg/ml)	112 ± 53	172 ± 60	1482 ± 498*	2854 ± 984*	4503 ± 689*^#	4214 ± 820*^#	4150 ± 813*^#
FGF-23 (pg/ml)	104 ± 18	115 ± 12	2554 ± 892*	5415 ± 694*	4508 ± 1102*	4040 ± 951*	5666 ± 3704*

BUN, blood urea nitrogen; 24 h CCr, 24 hour creatinine clearance; FEphos, fractional excretion of phosphorus; ALP, alkaline phosphatase; PTH, parathyroid hormone; FGF-23, fibroblast growth factor 23.

The data are represented as the means ± SEM (n = 5).

*P < 0.05, **P < 0.01 vs C6 and C12 by non-repeated measures ANOVA.

^# P < 0.01, ^## P < 0.01 vs A6 by non-repeated measures ANOVA.

^δ P < 0.05, ^δδ P < 0.01 vs A12 by non-repeated measures ANOVA.