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. 2005 Jan 13;115(2):459–467. doi: 10.1172/JCI22462

Figure 2.

Figure 2

Th2-mediated lung inflammation can occur in the absence of MyD88. (A) BAL inflammatory cells of WT and MyD88-deficient mice sensitized with OVA/LPS intranasally or OVA/alum i.p. Exposed mice were then challenged 2 weeks later with inhaled OVA. Total bar height represents total BAL cell number at day 21 after challenge. Error bars are based on total cell numbers. Stacked bars represent cell differential counts. n = 4. *P < 0.05, WT vs. MyD88-deficient mice primed with OVA/LPS. One representative experiment of 3 is shown. (B) BAL inflammatory cells of WT and MyD88-deficient mice sensitized intranasally with OVA/LPS or OVA/TNF-α. Exposed mice were then challenged 2 weeks later with inhaled OVA. Total bar height represents total BAL cell number at day 21 after challenge. Error bars are based on total cell numbers. Stacked bars represent cell differential counts. n = 4. *P < 0.05, WT vs. MyD88-deficient mice primed with OVA/LPS. One representative experiment of 3 is shown.