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. 2017 May 22;7:2232. doi: 10.1038/s41598-017-01513-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Big brown bat TNFα promoter has a unique c-Rel motif. Human and big brown bat TNFα promoters were analyzed for NFκB and c-Rel transcription factor binding sites. Human TNFα promoter has three NFκB binding and no c-Rel binding site. Big brown bat TNFα promoter has two NFκB binding site and one c-Rel binding site. Other transcription factor binding sites, including sites for NFκB-1 and Rel-A, are not shown here.