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. 2017 May 22;7:2235. doi: 10.1038/s41598-017-02367-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heatmap of plasma metabolites, excluding steroids and unknown compounds, significantly associated in linear regression analyses with either androstenedione (AD), testosterone (TT), dehydroepiandrosterone sulfate (DHEAS) or sex hormone-binding globulin (SHBG) in men (left panel) and women (right panel), respectively. Orange shading denotes positive and blue shading inverse associations. Dots indicate significant associations by controlling the false discovery rate (FDR) at 5%. Metabolites were grouped according to physiological entities as denoted on the left. Corresponding estimates and FDR values from linear regression analyses can be found in Tables S1 and S2. *Metabolites were annotated based on fragmentation spectra.