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. 2017 May 22;7:2252. doi: 10.1038/s41598-017-02293-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic illustration experimental design. Mice were divided into three groups, bleomycin was instilled on Day 0 in all these three groups. Treatment drugs were administered 3 days before bleomycin instillation and till to Day 7 in P Group, were administered 3 days prior to bleomycin and up to Day 21 in P&T Group, and were given to the mice from Day 10 to 24 in T group. P: Prevention; T: Therapy; B: Bleomycin; Drugs: Shenks or CYC.