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. 2017 May 22;7:2252. doi: 10.1038/s41598-017-02293-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Shenks inhibition on bleomycin (BLM)-induced mice lung fibrosis. (A) Histological findings revealed by both H&E and Masson’s staining of lung inflammation and fibrosis in mice treated with saline and placebo, mice treated with bleomycin and placebo, and mice treated with bleomycin and Shenks or CYC. Original magnification x400. (B) Lung collagen content as determined by Sircol assay (n = 6 mice per group). (C,D,E) Collagen mRNA levels in murine lungs examined by RT-PCR. mRNA levels were calculated using a relative ratio to Gapdh. (F,G) Ctgf and TGF-β mRNA levels in murine lungs examined by RT-PCR. mRNA levels were calculated using a relative ratio to Gapdh. Values in (B,C,D,E and F) are mean ± SEM from six mice per group. *P < 0.05, **P < 0.001 when compared with mice treated with bleomycin and placebo. H&E = Hematoxylin and eosin.