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. 2017 May 22;7:2252. doi: 10.1038/s41598-017-02293-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Shenks inhibition on collagen production. (A) Relative transcript levels of Col1a2 and Col3a1 in murine 3T3 fibroblasts that were exposed to different treatments. The expression level of each gene in the control group was normalized to 1. (B) Collagen content was determined by Sircol assay from the supernatants of cells that underwent different treatments. (C) Western blot analysis of type I collagen (COL1) in murine 3T3 fibroblasts that were exposed to different treatments. Densitometric analysis of Western blots for type I collagen (COL1) are shown. Bars indicate the mean ± SEM results of three assays. *P < 0.05; **P < 0.001. Control = PBS treated group; TGF-β = TGF-β-treated group; TGF-β + Shenks = TGF-β and Shenks treated group.