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. 2017 May 22;7:2229. doi: 10.1038/s41598-017-02494-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The correlation of HMGA2 expression with VM in clinical samples. (A) Phenomena of VM (yellow arrow, CD34-negative and PAS positive) and EDV (black arrow, CD34-positive and PAS-positive) in gastric carcinoma specimens; (B) IHC staining of HMGA2, the left for positive and the right for negative nuclear expression (×400, bar 50 um); (C) Quantum analysis of the correlation of HMGA2 with VM. A positive correlation between HMGA2 and VM using the Pearson correlation was observed (*P < 0.001, r = 0.4194) (D,E,F) Kaplan-Meier survival curve demonstrated that HMGA2 expression (D), VM (E), and a combination of HMGA2 expression and VM density (F) are significantly related to poor prognosis. (Log Rank χ² = 10.693, P = 0.001; Log Rank χ² = 8.413, P = 0.004; Log Rank χ² = 14.494, P = 0.001).