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. 2017 May 22;7:2229. doi: 10.1038/s41598-017-02494-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HMGA2 upregulates Twist1 and VE-cadherin expression in GC cell lines. (A) Immunofluorescence staining. Overexpression of HMGA2 increased the expression of Twist1 and VE-cadherin, while HMGA2 silencing inhibited Twist1 and VE-cadherin expression (bar, 50 um). Western blot (B) and semi-quantitative RT-PCR (C) were performed to analyze the expression of Twist1 and VE-cadherin in GC cells (*P < 0.05). The results show that Overexpression HMGA2 induced upregulation of Twist1 and VE-cadherin expression, the inverse change were obtained with the knockdown of HMGA2.