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. 2017 May 22;7:2215. doi: 10.1038/s41598-017-02509-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serotonergic modulation of noxious stimulus-evoked dorsal horn neuron activity is age-dependent. Pinch-evoked activity of dorsal horn WDR neurons was recorded at P8 and P21 and in adult rats. A typical recording of pinch-evoked dorsal horn neuron firing activity in adult control (A) and (A′) 5,7- DHT-treated rats. Pinch-evoked firing activity was significantly lower in 5,7-DHT-treated animals compared to controls at P8 (B) and P21 (C), but higher in adult rats (D). Pinch receptive fields were mapped on to a standardised paw template to create heat maps for control and 5,7-DHT-treated rats in P8 (E) and adult rats (E′). A typical dorsal horn neuron pinch receptive field from a P8 control rat is shown. Pinch receptive field area was significantly smaller in 5,7-DHT-treated compared to control at P8 (F) and P21 (G), but not in adult rats (H). Dorsal horn neuron responses to increasing forces of von Frey hairs (vFh) was lower in 5,7-DHT-treated compared to controls at P21 (J), but not in P8 (I), or adult rats (K). Bars indicate mean ± SEM. *^,**^,***P < 0.05, 0.01, 0.001.