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. 2017 May 22;7:2215. doi: 10.1038/s41598-017-02509-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RVM stimulation facilitates dorsal horn neuron activity at P21, but not following ablation of serotonergic terminals. (A) Timeline of experiments: brush and pinch-evoked dorsal horn neuron activity was recorded at baseline, during 10 μA stimulation, and during 100 μA stimulation of the RVM. RVM stimulation electrode sites are shown in (B). Typical traces of pinch-evoked dorsal horn neuron activity during RVM stimulation bouts are shown in a saline control rat (C) and a 5,7-DHT treated rat (D). 10 μA and 100 μA RVM stimulation facilitated mean pinch-evoked firing activity in saline-treated rats (E), but not 5,7-DHT treated rats (F). RVM stimulation increased pinch-evoked firing activity relative to baseline in many individual neurons in saline-treated rats, but not in 5,7-DHT-treated rats (G). RVM stimulation increased pinch evoked activity in the majority of cells (>20% firing activity relative to baseline pinch) in saline-treated rats upon (H), while in 5,7-DHT treated rats, pinch evoked activity was reduced in a subset of cells (<20% firing activity relative to baseline pinch) by RVM stimulation (H). RVM stimulation did not change mean brush-evoked firing activity in saline (I) or 5,7-DHT-treated rats (J). Bars indicate mean ± SEM. **P < 0.01 versus baseline 1; ^##,###P < 0.01, 0.001 versus baseline 2.